Johnstone Laboratory | UCSC

Simms, M. E.; Li, Z.; Sibley, M. M.; Ivanov, A. S.; Lara, C. M.; Johnstone, T. C.; Kertesz, V.; Fears, A.; White, F. D.; Thorek, D. L. J.; Thiele, N. A.

Chem. Sci. 2024, 15, 11279–11286.

*Featured on Chemical Science cover.

71. Recent advances in the stabilization of monomeric stibinidene chalcogenides and stibine chalcogenides

Wenger, J. S.; Johnstone, T. C.

Dalton Trans. 2024, 53, 8524–8534.

*Selected as a HOT Article (top 10% of research published in Dalton Transactions each quarter).

70. Chemical Structure Elucidation in the Development of Inorganic Drugs: Evidence from Ru-, Au-, As-, and Sb-based Medicines

Lance-Byrne, A.; Lindquist-Kleissler, B.; Johnstone, T. C.

Eur. J. Inorg. Chem. 2024, 27, e202300717.

*Invited contribution to the EurJIC Talents special issue.

*One of the top 10% most-read papers in Eur. J. Inorg. Chem. in 2024.

69. Carbon monoxide poisoning: A problem uniquely suited to a medicinal inorganic chemistry solution

Parker, A. L.; Johnstone, T. C.

J. Inorg. Biochem. 2024, 251, 112453.

*Invited contribution to the Recent Advances in BioInorganic Chemistry from CanBic8 special issue.

68. Steric congestion in heavy pnictines alters oxidative halogenation pathways

Wenger, J. S.; Getahun, A.; Johnstone, T. C.

Polyhedron 2024, 247, 116730.

*Invited contribution to the Emerging Investigators in Inorganic Chemistry special issue.

*Recipient of one of the 2024 Best Paper Awards from Polyhedron.

67. Variation in Pnictogen–Oxygen Bonding Unlocks Greatly Enhanced Brønsted Basicity for the Monomeric Stibine Oxide

Wenger, J. S.; Getahun, A.; Johnstone, T. C.

Dalton Trans. 2023, 52, 11325–11334.

66. The Role of Metals in the Next Generation of Anticancer Therapeutics

Wilson, J. J.; Johnstone, T. C.

Curr. Opin. Chem. Biol. 2023, 76, 102363.

65. Models of the Putative Antimony(V)-Diolate Motifs in Antileishmanial Pentavalent Antimonial Drugs

Lindquist-Kleissler, B.; Johnstone, T. C.

Dalton Trans. 2023, 52, 9229–9237.

*Selected as a HOT Article (top 10% of research published in Dalton Transactions each quarter).

64. Isolation, Bonding and Reactivity of a Monomeric Stibine Oxide

Wenger, J. S.; Weng, M.; George, G. N.; Johnstone, T. C.

Nat. Chem. 2023, 15, 633–640.

*Highlighted in Nature Chemistry News and Views.

63. Realgar and Arsenene Nanomaterials as Arsenic-Based Anticancer Agents

Hollow, S E.; Johnstone, T. C.

Curr. Opin. Chem. Biol. 2023, 72, 102229.

62. Selective Chromium(VI) Trapping by an Acetate-Releasing Coordination Polymer

Conour, C. S.; Droege, D. G.; Ehlke, B.; Johnstone, T. C.; Oliver, S. R. J.

Inorg. Chem. 2022, 61, 20824–20833.

61. Synthesis and Functionalization of Challenging meso-Substituted Aryl Bis-pocket Porphyrins Accessed via Suzuki–Miyaura Cross-Coupling

Droege, D. G.; Parker, A. L.; Milligan, G. M.; Jenkins, R.; Johnstone, T. C.

J. Org. Chem. 2022, 87, 11783–11795.

60. Biomimetic Total Synthesis and Investigation of the Non‑Enzymatic Chemistry of Oxazinin A

Aniebok, V.; Shingare, R. D.; Lee, H.-W.; Johnstone, T. C.; MacMillan, J. B.

Angew. Chem., Int. Ed. 2022, 61, e202208029.

59. The Rippled β-sheet Layer Configuration—A Novel Supramolecular Architecture Based on Predictions by Pauling and Corey

Hazari, A.; Sawaya, M. R.; Vlahakis, N.; Johnstone, T. C.; Boyer, D.; Rodriguez, J.; Eisenberg, D.; Raskatov, J. A.

Chem. Sci. 2022, 13, 8947–8952.

58. A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding

Taechalertpaisarn, J.; Ono, S.; Okada, O.; Johnstone, T. C.; Lokey, R. S.

J. Med. Chem. 2022, 65, 5072–5084.

57. A Water-Soluble Iron-Porphyrin Complex Capable of Rescuing CO-Poisoned Red Blood Cells

Droege, D. G.; Johnstone, T. C.

Chem. Commun. 2022, 58, 2722–2725.

*Featured in Tech Explorist, UCSC News, Science Daily, Nouvelles du monde, The Medical News, Today UK News, Thinking Port, Laboratory Equipment, Phys.org, EurekAlert!, Bioengineer.org, Mirage News, and ScienMag

56. Encapsulation of closo-Dodecaiodododecaborate in 2-Hydroxypropyl-γ-cyclodextrin Prevents Hemolysis

Hollow, S. E.; Johnstone, T. C.

Chem. Commun. 2022, 58, 2375–2378.

*Invited contribution to "Boron Chemistry in the 21st Century: From Synthetic Curiosities to Functional Molecules"

*Featured in Cyclodextrin News

55. A Crystal-Structural Study of Pauling-Corey Rippled Sheets

Kuhn, A. J.; Ehlke, B.; Johnstone, T. C.; Oliver, S. J. R.; Raskatov, J. A.

Chem. Sci. 2022, 13, 671–680.

*Invited cover, featured in Science Springs, UCSC News, EurekAlert!, Phys.Org, Mirage News, and ScienMag

54. H-Atom Assignment and Sb–O Bonding of [Mes3SbOH][O3SPh] Confirmed by Neutron Diffraction, Multipole Modeling, and Hirshfeld Atom Refinement

Wenger, J. S.; Wang, X.; Johnstone, T. C.

Inorg. Chem. 2021, 60, 16048–16052.

53. Genomics-Driven Discovery of Chiral Triscatechol Siderophores with Enantiomeric Fe(III) Coordination

Stow, P. R.; Reitz, Z. L.; Johnstone, T. C.; Butler, A.

Chem. Sci. 2021, 12, 12485–12493.

52. Geometry of Pentaphenylantimony in Solution: Support for a Trigonal Bipyramidal Assignment from X-ray Absorption Spectroscopy and Vibrational Spectroscopic Data

Lindquist-Kleissler, B.; Weng, M.; Le Margueres, P.; George, G. N.; Johnstone, T. C.

Inorg. Chem. 2021, 60, 8566–8574.

51. Unsupported Monomeric Stibine Oxides (R3SbO) Remain Undiscovered

Wenger, J. S.; Johnstone, T. C.

Chem. Commun. 2021, 57, 3484–3487.

50. Analysis of Oxygen–Pnictogen Bonding with Full Bond Path Topological Analysis of the Electron Density

Lindquist-Kleissler, B.; Wenger, J. S.; Johnstone, T. C.

Inorg. Chem. 2021, 60, 1846–1856.

49. Enterobactin- and Salmochelin-β-lactam Conjugates Induce Cell Morphologies Consistent with Inhibition of Penicillin-Binding Proteins in Uropathogenic Escherichia coli CFT073

Sargun, A.; Johnstone, T. C.; Zhi, H.; Raffatellu, M.; Nolan, E. M.

Chem. Sci. 2021, 12, 4041–4056.

48. Frustrated Lewis Pair Pedagogy: Expanding Core Undergraduate Curriculum and Reinforcing Fundamental Thermodynamic Concepts

Johnstone, T. C.

in Frustrated Lewis Pairs. Molecular Catalysis, vol 2, 2021, 387-400.

47. A “Push–Pull” Stabilized Phosphinidene Supported by a Phosphine‐Functionalized β‐Diketiminato Ligand

Bestgen, S.; Mehta, M.; Johnstone, T. C.; Roesky, P. W.; Goicoechea, J. M.

Chem.–Eur. J. 2020, 26, 9024–9031.

46. Computer-Aided Identification of Symmetry Relating Groups of Molecules

Ruiz, G. N.; Johnstone, T. C.

J. Chem. Educ. 2020, 97, 1604–1612.

Prior to UCSC

45. Using Frustrated Lewis Pairs to Explore C–F Bond Activation

Briceno-Strocchia, A. I.; Johnstone, T. C.; Stephan, D. W.

Dalton Trans. 2020, 49, 1319–1324.

*Selected as a HOT Article (top 10% of research published in Dalton Transactions each quarter).

44. Frustrated Lewis Pair Oxidation Permits Synthesis of a Fluoroazaphosphatrane, [FP(MeNCH2CH2)3N]+

Johnstone, T. C.; Briceno-Strocchia, A. I.; Stephan, D. W.

Inorg. Chem. 2018, 57, 15299–15304.

43. Improving the Global Electrophilicity Index (GEI) as a Measure of Lewis Acidity

Jupp, A. R.; Johnstone, T. C.; Stephan, D. W.

Inorg. Chem. 2018, 57, 14764–14771.

42. Synthesis of Selected Transition Metal and Main Group Compounds with Synthetic Applications: (1R,2R-Diaminocyclohexane)oxalatoplatinum(II), Oxaliplatin

Johnstone, T. C.; Checked by Starha, P.; Habtemariam, A.

Inorg. Synth. 2018, 37, 179–183.

41. Probing Steric Influences on Electrophilic Phosphonium Cations: A Comparison of [(3,5-(CF3)2C6H3)3PF]+ and [(C6F5)3PF]+

LaFortune, J. H. W.; Szkop, K. M.; Farinha, F. E.; Johnstone, T. C.; Postle, S.; Stephan, D. W.

Dalton Trans. 2018, 47, 11411–11419.

40. The Global Electrophilicity Index as a Metric for Lewis Acidity

Jupp, A. R.; Johnstone, T. C.; Stephan, D. W.
Dalton Trans. 2018, 47, 7029–7035.

39. Accessing FLP Chemistry from a Spectroscopically Stable Classical Lewis Acid-Base Adduct

Johnstone, T. C.; Wee, G. N. J. H.; Stephan, D. W.

Angew. Chem., Int. Ed. 2018, 57, 5881–5884.

Angew. Chem. 2018, 130, 5983–5986.

38. Catalytic Double Hydroarylation of Alkynes to 9,9-Disubstituted 9,10-Dihydroacridine Derivatives by an Electrophilic Phenoxyphosphonium Dication

LaFortune, J. H. W.; Bayne, J. M.; Johnstone, T. C.; Fan, L.; Stephan, D. W

Chem. Commun. 2017, 53, 13312–13315.

*Invited front cover

37. 1,1-Hydroboration and a Borane Adduct of Diphenyldiazomethane: A Potential Prelude to FLP-N2 Chemistry

Tang, C.; Liang, Q.; Jupp, A. R.; Johnstone, T. C.; Neu, R. C.; Song, D.; Grimme, S.; Stephan, D. W.

Angew. Chem., Int. Ed. 2017, 56, 16588–16592.

Angew. Chem. 2017, 129, 16815–16819.

*Highlighted by Angew. Chem., Int. Ed. in DOI: 10.1002/anie.201711945

36. Dicationic Phosphonium Salts: Lewis Acid Catalysts for the Mukaiyama–Aldol Reaction

Barrado, A. G.; Bayne, J. M.; Johnstone, T. C.; Lehmann, C. W.; Stephan, D. W.; Alcarazo, M.

Dalton Trans. 2017, 46, 16216–16227.

35. Determination of the Molecular Structures of Ferric Enterobactin and Ferric Enantioenterobactin using Racemic Crystallography

Johnstone, T. C.; Nolan, E. M.

J. Am. Chem. Soc. 2017, 139, 15245–15250.

*Selected for the JACS 2018 Young Investigators Virtual Issue

34. Synthesis and Oxidation of Phosphine Cations

Mehta, M.; Johnstone, T. C.; Lam, J.; Bagh, B.; Hermannsdorfer, A.; Driess, M.; Stephan, D. W.

Dalton Trans. 2017, 46, 14149–14157.

33. A Model for C–F Activation by Electrophilic Phosphonium Cations

Mallov, I.; Johnstone, T. C.; Burns, D. C.; Stephan, D. W.

Chem. Commun. 2017, 53, 7529–7532.

32. Quantifying the Efficiency of CO2 Capture by Lewis Pairs

Chi, J. J.; Johnstone, T. C.; Voicu, D.; Mehlmann, P.; Dielmann, F.; Kumacheva, E.; Stephan, D. W.

Chem. Sci. 2017, 8, 3270–3275.

31. Electrophilic Phenoxy-substituted Phosphonium Cations

Lafortune, J.; Johnstone, T. C.; Pérez, M.; Winkelhaus, D.; Podgorny, V.; Stephan, D. W.

Dalton Trans., 2016, 45, 18156-18162.

30. Hydroboration of Phosphaalkynes by HB(C6F5)2

Longobardi, L. E.; Johnstone, T. C.; Falconer, R.; Russell, C. A.; Stephan, D. W.

Chem.–Eur. J. 2016, 22, 12665–12669.

29. Nucleotide Binding Preference of the Monofunctional Platinum Anticancer Agent Phenanthriplatin

Riddell, I. A.; Johnstone, T. C.; Lippard, S. J.

Chem.–Eur. J. 2016, 22, 7574–7581.

28. Cationic Aluminum Hydride Complexes: Reactions of Carbene-Alane Adducts with Trityl-Borate

Cao, L.L.; Daley, E.; Johnstone, T. C.; Stephan, D. W.

Chem. Commun. 2016, 52, 5305–5307.

27. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Johnstone, T. C.; Suntharalingam, K.; Lippard, S. J.

Chem. Rev. 2016, 116, 3436–3486.

26. A Potent Glucose–Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

Patra, M.; Johnstone, T. C.; Sunthalingam, K.; Lippard, S. J.

Angew. Chem., Int. Ed. 2016, 55, 2550–2554.

Angew. Chem. 2016, 128, 2596–2600.

25. Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus

Madsen, J. H. L.; Johnstone, T. C.; Nolan, E. M.

J. Am. Chem. Soc. 2015, 137, 9117–9127.

24. Beyond Iron: Non-Classical Functions of Bacterial Siderophores

Johnstone, T. C.; Nolan, E. M.

Dalton Trans. 2015, 44, 6320–6339.

23. Cisplatin and Related Drugs

Johnstone, T. C.; Pil, P. M.; Lippard, S. J.

Reference Module in Biomedical Sciences, 2015 (ISBN: 978-0-12-801238-3)

Update to: Encyclopedia of Cancer (Second Edition), 2002, 525–543.

22. Necroptosis-Inducing Rhenium(V) Oxo Complexes

Suntharalingam,K.; Awuah, S.; Bruno, P.; Johnstone, T. C.; Wang, F.; Lin, W.; Zheng, Y.-R.; Page, J.; Hemann, M. T.; Lippard, S. J.

J. Am. Chem. Soc. 2015, 137, 2967–2974.

21. Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery

Zheng, Y.-R.; Suntharalingam, K.; Johnstone, T. C.; Lippard, S. J.

Chem. Sci. 2015, 6, 1189–1193.

20. Third Row Transition Metals for the Treatment of Cancer

Johnstone, T. C.; Suntharalingam, K.; Lippard, S. J.

Phil. Trans. R. Soc. A 2015, 373, 20140185.

19. Oxidative Halogenation of Cisplatin and Carboplatin: Synthesis, Spectroscopy, and Crystal and Molecular Structures of Pt(IV) Prodrugs

Johnstone, T. C.; Alexander, S. M.; Wilson, J. J.; Lippard S. J.

Dalton Trans. 2015, 44, 119–129.

18. Improvements in the Synthesis and Understanding of the Iodo-bridged Intermediate en Route to the Pt(IV) Prodrug Satraplatin

Johnstone, T. C.; Lippard, S. J.

Inorg. Chim. Acta 2015, 424, 254–259.

17. A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex

Suntharalingam, K.; Lin, W.; Johnstone, T. C.; Lippard S. J.

J. Am. Chem. Soc. 2014, 136, 14413–14416.

16. Pt(IV) Prodrugs Designed to Bind to Human Serum Albumin for Drug Delivery

Zheng, Y.-R.; Suntharalingam, K.; Johnstone, T. C.; Yoo, H.; Lin, W.; Brooks, J. G.; Lippard, S. J.

J. Am. Chem. Soc. 2014, 136, 8790–8798.

15. Structural and Mechanistic Studies of Polymerase η Bypass of Phenanthriplatin DNA Damage

Gregory, M. T.; Park, G. Y.; Johnstone, T. C., Lee, Y.-S.; Yang, W.; Lippard, S. J.

Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 9133–9138.

14. Reinterpretation of the Vibrational Spectroscopy of the Medicinal Bioinorganic Synthon c,c,t-[Pt(NH3)2Cl2(OH)2]

Johnstone, T. C.; Lippard, S. J.

J. Biol. Inorg. Chem. 2014, 19, 667–674.

13. A Fast and Selective Near-Infrared Fluorescent Sensor for Multicolor Imaging of Biological Nitroxyl

Wrobel, A. T.; Johnstone, T. C.; Deliz-Liang, A.; Lippard, S. J.; Rivera Fuentes, P. M.

J. Am. Chem. Soc. 2014, 136, 4697–4705.

12. The Chiral Potential of Phenanthriplatin and the Influence It Has on Guanine Binding

Johnstone, T. C.; Lippard, S. J.

J. Am. Chem. Soc. 2014, 136, 2126–2134.

11. Effects of Monofunctional Platinum Agents on Bacterial Growth: A Retrospective Study

Johnstone, T. C.; Alexander, S. M.; Lin, W.; Lippard, S. J.

J. Am. Chem. Soc. 2014, 136, 116–118.

10. Understanding and Improving Platinum Anticancer Drugs – Phenanthriplatin

Johnstone, T. C.; Park, G. Y.; Lippard, S. J.

Anticancer Res. 2014, 34, 471–476.

9. The Crystal Structure of Oxaliplatin: A Case of Overlooked Pseudo Symmetry

Johnstone, T. C.

Polyhedron 2014, 67, 429–435.

8. Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways

Suntharalingam, K.; Johnstone, T. C.; Bruno, P. M.; Lin, W.; Hemann, M. T.; Lippard, S. J.

J. Am. Chem. Soc. 2013, 135, 14060–14063.

*Highlighted by Chemical Research in Toxicology in DOI: 10.1021/tx4003897

7. Monofunctional and Higher-Valent Platinum Anticancer Agents

Johnstone, T. C.; Wilson, J. J.; Lippard, S. J.

Inorg. Chem. 2013, 52, 12234–12249.

*Inorganic Chemistry Forum Issue on Metals in Health and Medicine

6. The Effect of Ligand Lipophilicty on the Nanoparticle Encapsulation of Pt(IV) Prodrugs

Johnstone, T. C.; Lippard, S. J.

Inorg. Chem. 2013, 52, 9915–9920.

*Invited front cover

5. Nanoparticle Encapsulation of Mitaplatin and the Effect Thereof on In Vitro Properties

Johnstone, T. C.; Kulak, N.; Prigden, E. M.; Farokhzad, O. C.; Langer, R.; Lippard, S. J.

ACS Nano 2013, 7, 5675–5683.

*Highlighted by ACS Nano in DOI: 10.1021/nn403220e

4. Conformational Isomerism of trans-[Pt(NH2C6H11)2I2] and the Classical Wernerian Chemistry of [Pt(NH2C6H11)4]X2 (X = Cl, Br, I)

Johnstone, T. C.; Lippard, S. J.

Polyhedron 2013, 52, 565–575.

3. Permethylated Salts and Radicals Derived from Azo peri-Naphthalenes

Bohle, D.; Chua, Z.; Johnstone, T.; Perepichka, I.; Rosadiuk, K.

ChemPlusChem 2012, 77, 387–395.

2. Reinforcement with Cellulose Nanocrystals of Poly(vinyl alcohol) Hydrogels Prepared by Cyclic Freezing and Thawing

Abitbol, T.; Johnstone, T.; Quinn, T. M.; Gray, D. G.

Soft Matter 2011, 7, 2373–2379.

1. Hydrogen-Bonding Asymmetric Metal Catalysis with alpha-Amino Acids: A Simple and Tunable Approach to High Enantioinduction

Lu, Y. D.; Johnstone, T. C.; Arndtsen, B. A.

J. Am. Chem. Soc. 2009, 131, 11284–11285.

The Johnstone Laboratory

Medicinal and Fundamental Inorganic Chemistry Research Group

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