The Johnstone Laboratory

75. Perhalogenated Anions as Structure Directing Agents of Cationic Coordination Polymers

Lofgren, K. C.; Fusari, K. J.; Droege, D. G.; Barnett, J. L.; Johnstone, T. C.; Oliver, S. R. J.

Cryst. Growth Des. 2024, 24, 7847-7857.

 

74. Reactivity of Tetrel-Functionalized Heptaphosphane Clusters toward Azides

Jobbins, W. D.; Cullen, R. T.; Stott, T.; van IJzendoorn, B.; Réant, B. L. L.; Johnstone, T. C.; Mehta, M.

Inorg. Chem. 2024, 63, 13807-13814.

*ACS Editors' Choice

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73. A Sterically Accessible Monomeric Stibine Oxide Activates Organotetrel(IV) Halides, Including C–F and Si–F Bonds

Wenger, J. S.; Johnstone, T. C.

J. Am. Chem. Soc. 2024, 146, 19350-19359.

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72. PYTA: a universal chelator for advancing the theranostic palette of nuclear medicine

Simms, M. E.; Li, Z.; Sibley, M. M.; Ivanov, A. S.; Lara, C. M.; Johnstone, T. C.; Kertesz, V.; Fears, A.; White, F. D.; Thorek, D. L. J.; Thiele, N. A.

Chem. Sci. 2024, 15, 11279-11286.

*Featured on Chemical Science cover.

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71. Recent advances in the stabilization of monomeric stibinidene chalcogenides and stibine chalcogenides

Wenger, J. S.; Johnstone, T. C.

Dalton Trans. 2024, 53, 8524-8534.

*Selected as a HOT Article (top 10% of research published in Dalton Transactions each quarter).

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70. Chemical Structure Elucidation in the Development of Inorganic Drugs: Evidence from Ru-, Au-, As-, and Sb-based Medicines

Lance-Byrne, A.; Lindquist-Kleissler, B.; Johnstone, T. C.

Eur. J. Inorg. Chem. 2024, 27, e202300717.

*Invited contribution to the EurJIC Talents special issue.

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69. Carbon monoxide poisoning: A problem uniquely suited to a medicinal inorganic chemistry solution

Parker, A. L.; Johnstone, T. C.

J. Inorg. Biochem. 2024, 251, 112453.

*Invited contribution to the Recent Advances in BioInorganic Chemistry from CanBic8 special issue.

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68. Steric congestion in heavy pnictines alters oxidative halogenation pathways

Wenger, J. S.; Getahun, A.; Johnstone, T. C.

Polyhedron 2024, 247, 116730.

*Invited contribution to the Emerging Investigators in Inorganic Chemistry special issue.

*Recipient of the 2024 Best Paper Award from Polyhedron.

 

67. Variation in Pnictogen–Oxygen Bonding Unlocks Greatly Enhanced Brønsted Basicity for the Monomeric Stibine Oxide

Wenger, J. S.; Getahun, A.; Johnstone, T. C.

Dalton Trans. 2023, 52, 11325-11334.

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66. The Role of Metals in the Next Generation of Anticancer Therapeutics

Wilson, J. J.; Johnstone, T. C.

Curr. Opin. Chem. Biol. 2023, 76, 102363.

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65. Models of the Putative Antimony(V)-Diolate Motifs in Antileishmanial Pentavalent Antimonial Drugs

Lindquist-Kleissler, B.; Johnstone, T. C.

Dalton Trans. 2023, 52, 9229-9237.

*Selected as a HOT Article (top 10% of research published in Dalton Transactions each quarter).

 

64. Isolation, Bonding and Reactivity of a Monomeric Stibine Oxide

Wenger, J. S.; Weng, M.; George, G. N.; Johnstone, T. C.

Nat. Chem. 2023, 15, 633-640.

*Highlighted in Nature Chemistry News and Views.

 

63. Realgar and Arsenene Nanomaterials as Arsenic-Based Anticancer Agents

Hollow, S E.; Johnstone, T. C.

Curr. Opin. Chem. Biol. 2023, 72, 102229.

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62. Selective Chromium(VI) Trapping by an Acetate-Releasing Coordination Polymer

Conour, C. S.; Droege, D. G.; Ehlke, B.; Johnstone, T. C.; Oliver, S. R. J.

Inorg. Chem. 2022, 61, 20824-20833.

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61. Synthesis and Functionalization of Challenging meso-Substituted Aryl Bis-pocket Porphyrins Accessed via Suzuki–Miyaura Cross-Coupling

Droege, D. G.; Parker, A. L.; Milligan, G. M.; Jenkins, R.; Johnstone, T. C.

J. Org. Chem. 2022, 87, 11783-11795.

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60. Biomimetic Total Synthesis and Investigation of the Non‑Enzymatic Chemistry of Oxazinin A

Aniebok, V.; Shingare, R. D.; Lee, H.-W.; Johnstone, T. C.; MacMillan, J. B.

Angew. Chem., Int. Ed. 2022, 61, e202208029.

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59. The Rippled β-sheet Layer Configuration—A Novel Supramolecular Architecture Based on Predictions by Pauling and Corey

Hazari, A.; Sawaya, M. R.; Vlahakis, N.; Johnstone, T. C.; Boyer, D.; Rodriguez, J.; Eisenberg, D.; Raskatov, J. A.

Chem. Sci. 2022, 13, 8947-8952.

 

58. A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding

Taechalertpaisarn, J.; Ono, S.; Okada, O.; Johnstone, T. C.; Lokey, R. S.

J. Med. Chem. 2022, 65, 5072-5084.

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57. A Water-Soluble Iron-Porphyrin Complex Capable of Rescuing CO-Poisoned Red Blood Cells

Droege, D. G.; Johnstone, T. C.

Chem. Commun. 2022, 58, 2722-2725.

*Featured in Tech Explorist, UCSC News, Science Daily, Nouvelles du monde, The Medical News, Today UK News, Thinking Port, Laboratory Equipment, Phys.org, EurekAlert!, Bioengineer.org, Mirage News, and ScienMag

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56. Encapsulation of closo-Dodecaiodododecaborate in 2-Hydroxypropyl-γ-cyclodextrin Prevents Hemolysis

Hollow, S. E.; Johnstone, T. C.

Chem. Commun. 2022, 58, 2375-2378.

*Invited contribution to "Boron Chemistry in the 21st Century: From Synthetic Curiosities to Functional Molecules"

*Featured in Cyclodextrin News

 

55. A Crystal-Structural Study of Pauling-Corey Rippled Sheets

Kuhn, A. J.; Ehlke, B.; Johnstone, T. C.; Oliver, S. J. R.; Raskatov, J. A.

Chem. Sci. 2022, 13, 671-680.

*Invited cover, featured in Science Springs, UCSC News, EurekAlert!, Phys.Org, Mirage News, and ScienMag

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54. H-Atom Assignment and Sb–O Bonding of [Mes3SbOH][O3SPh] Confirmed by Neutron Diffraction, Multipole Modeling, and Hirshfeld Atom Refinement

Wenger, J. S.; Wang, X.; Johnstone, T. C.

Inorg. Chem. 2021, 60, 16048-16052.

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53. Genomics-Driven Discovery of Chiral Triscatechol Siderophores with Enantiomeric Fe(III) Coordination

Stow, P. R.; Reitz, Z. L.; Johnstone, T. C.; Butler, A.

Chem. Sci. 2021, 12, 12485-12493.

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52. Geometry of Pentaphenylantimony in Solution: Support for a Trigonal Bipyramidal Assignment from X-ray Absorption Spectroscopy and Vibrational Spectroscopic Data

Lindquist-Kleissler, B.; Weng, M.; Le Margueres, P.; George, G. N.; Johnstone, T. C.

Inorg. Chem. 2021, 60, 8566-8574.

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51. Unsupported Monomeric Stibine Oxides (R3SbO) Remain Undiscovered

Wenger, J. S.; Johnstone, T. C.

Chem. Commun. 2021, 57, 3484-3487.

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50. Analysis of Oxygen–Pnictogen Bonding with Full Bond Path Topological Analysis of the Electron Density

Lindquist-Kleissler, B.; Wenger, J. S.;  Johnstone, T. C.

Inorg. Chem. 2021, 60, 1846-1856.

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49. Enterobactin- and Salmochelin-β-lactam Conjugates Induce Cell Morphologies Consistent with Inhibition of Penicillin-Binding Proteins in Uropathogenic Escherichia coli CFT073

Sargun, A.; Johnstone, T. C.; Zhi, H.; Raffatellu, M.; Nolan, E. M.

Chem. Sci. 2021, 12, 4041-4056.

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48. Frustrated Lewis Pair Pedagogy: Expanding Core Undergraduate Curriculum and Reinforcing Fundamental Thermodynamic Concepts

Johnstone, T. C.

in Frustrated Lewis Pairs. Molecular Catalysis, vol 2, 2021, 387-400.

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47. A “Push–Pull” Stabilized Phosphinidene Supported by a Phosphine‐Functionalized β‐Diketiminato Ligand

Bestgen, S.; Mehta, M.; Johnstone, T. C.; Roesky, P. W.; Goicoechea, J. M.

Chem.–Eur. J. 2020, 26, 9024-9031.

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46. Computer-Aided Identification of Symmetry Relating Groups of Molecules

Ruiz, G. N.; Johnstone, T. C.

J. Chem. Educ. 2020, 97, 1604-1612.

 

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Prior to UCSC

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45. Using Frustrated Lewis Pairs to Explore C–F Bond Activation

Briceno-Strocchia, A. I.; Johnstone, T. C.; Stephan, D. W.

Dalton Trans. 2020, 49, 1319-1324.

*Selected as a HOT Article (top 10% of research published in Dalton Transactions each quarter).

 

44. Frustrated Lewis Pair Oxidation Permits Synthesis of a Fluoroazaphosphatrane, [FP(MeNCH2CH2)3N]+

Johnstone, T. C.; Briceno-Strocchia, A. I.; Stephan, D. W.

Inorg. Chem. 2018, 57, 15299-15304.

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43. Improving the Global Electrophilicity Index (GEI) as a Measure of Lewis Acidity

Jupp, A. R.; Johnstone, T. C.; Stephan, D. W.

Inorg. Chem. 2018, 57, 14764-14771.

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42. Synthesis of Selected Transition Metal and Main Group Compounds with Synthetic Applications: (1R,2R-Diaminocyclohexane)oxalatoplatinum(II), Oxaliplatin

Johnstone, T. C.; Checked by Starha, P.; Habtemariam, A.

Inorg. Synth. 2018, 37, 179-183.

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41. Probing Steric Influences on Electrophilic Phosphonium Cations: A Comparison of [(3,5-(CF3)2C6H3)3PF]+ and [(C6F5)3PF]+

LaFortune, J. H. W.; Szkop, K. M.; Farinha, F. E.; Johnstone, T. C.; Postle, S.; Stephan, D. W.

Dalton Trans. 2018, 47, 11411-11419.

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40. The Global Electrophilicity Index as a Metric for Lewis Acidity

Jupp, A. R.; Johnstone, T. C.; Stephan, D. W.
Dalton Trans. 2018, 47, 7029-7035.

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39. Accessing FLP Chemistry from a Spectroscopically Stable Classical Lewis Acid-Base Adduct

Johnstone, T. C.; Wee, G. N. J. H.; Stephan, D. W.

Angew. Chem., Int. Ed. 2018, 57, 5881-5884.

Angew. Chem. 2018, 130, 5983-5986.

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38. Catalytic Double Hydroarylation of Alkynes to 9,9-Disubstituted 9,10-Dihydroacridine Derivatives by an Electrophilic Phenoxyphosphonium Dication

LaFortune, J. H. W.; Bayne, J. M.; Johnstone, T. C.; Fan, L.; Stephan, D. W

Chem. Commun. 2017, 53, 13312-13315.

*Invited front cover

 

37. 1,1-Hydroboration and a Borane Adduct of Diphenyldiazomethane: A Potential Prelude to FLP-N2 Chemistry

Tang, C.; Liang, Q.; Jupp, A. R.; Johnstone, T. C.; Neu, R. C.; Song, D.; Grimme, S.; Stephan, D. W.

Angew. Chem., Int. Ed. 2017, 56, 16588-16592.

Angew. Chem. 2017, 129, 16815-16819.

*Highlighted by Angew. Chem., Int. Ed. in DOI: 10.1002/anie.201711945

 

36. Dicationic Phosphonium Salts: Lewis Acid Catalysts for the Mukaiyama–Aldol Reaction

Barrado, A. G.; Bayne, J. M.; Johnstone, T. C.; Lehmann, C. W.; Stephan, D. W.; Alcarazo, M.

Dalton Trans. 2017, 46, 16216-16227.

 

35. Determination of the Molecular Structures of Ferric Enterobactin and Ferric Enantioenterobactin using Racemic Crystallography

Johnstone, T. C.; Nolan, E. M.

J. Am. Chem. Soc. 2017, 139, 15245-15250.

*Selected for the JACS 2018 Young Investigators Virtual Issue

 

34. Synthesis and Oxidation of Phosphine Cations

Mehta, M.; Johnstone, T. C.; Lam, J.; Bagh, B.; Hermannsdorfer, A.; Driess, M.; Stephan, D. W.

Dalton Trans. 2017, 46, 14149-14157.

 

33. A Model for C–F Activation by Electrophilic Phosphonium Cations

Mallov, I.; Johnstone, T. C.; Burns, D. C.; Stephan, D. W.

Chem. Commun. 2017, 53, 7529-7532.

 

32. Quantifying the Efficiency of CO2 Capture by Lewis Pairs

Chi, J. J.; Johnstone, T. C.; Voicu, D.; Mehlmann, P.; Dielmann, F.; Kumacheva, E.; Stephan, D. W.

Chem. Sci. 2017, 8, 3270-3275.

 

31. Electrophilic Phenoxy-substituted Phosphonium Cations

Lafortune, J.; Johnstone, T. C.; Pérez, M.; Winkelhaus, D.; Podgorny, V.; Stephan, D. W.

Dalton Trans., 2016, 45, 18156-18162.

 

30. Hydroboration of Phosphaalkynes by HB(C6F5)2

Longobardi, L. E.; Johnstone, T. C.; Falconer, R.; Russell, C. A.; Stephan, D. W.

Chem.–Eur. J. 2016, 22, 12665-12669.

 

29. Nucleotide Binding Preference of the Monofunctional Platinum Anticancer Agent Phenanthriplatin

Riddell, I. A.; Johnstone, T. C.; Lippard, S. J.

Chem.–Eur. J. 2016, 22, 7574-7581.

 

28. Cationic Aluminum Hydride Complexes: Reactions of Carbene-Alane Adducts with Trityl-Borate

Cao, L.L.; Daley, E.; Johnstone, T. C.; Stephan, D. W.

Chem. Commun. 2016, 52, 5305-5307.

 

27. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Johnstone, T. C.; Suntharalingam, K.; Lippard, S. J.

Chem. Rev. 2016, 116, 3436-3486.

 

26. A Potent Glucose–Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

Patra, M.; Johnstone, T. C.; Sunthalingam, K.; Lippard, S. J.

Angew. Chem., Int. Ed. 2016, 55, 2550-2554.

Angew. Chem. 2016, 128, 2596-2600.

 

25. Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus

Madsen, J. H. L.; Johnstone, T. C.; Nolan, E. M.

J. Am. Chem. Soc. 2015, 137, 9117-9127.

 

24. Beyond Iron: Non-Classical Functions of Bacterial Siderophores

Johnstone, T. C.; Nolan, E. M.

Dalton Trans. 2015, 44, 6320-6339.

 

23. Cisplatin and Related Drugs

Johnstone, T. C.; Pil, P. M.; Lippard, S. J.

Reference Module in Biomedical Sciences, 2015 (ISBN: 978-0-12-801238-3)

Update to: Encyclopedia of Cancer (Second Edition), 2002, 525-543.

 

22. Necroptosis-Inducing Rhenium(V) Oxo Complexes

Suntharalingam,K.; Awuah, S.; Bruno, P.; Johnstone, T. C.; Wang, F.; Lin, W.; Zheng, Y.-R.; Page, J.; Hemann, M. T.; Lippard, S. J.

J. Am. Chem. Soc. 2015, 137, 2967-2974.

 

21. Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery

Zheng, Y.-R.; Suntharalingam, K.; Johnstone, T. C.; Lippard, S. J.

Chem. Sci. 2015, 6, 1189-1193.

 

20. Third Row Transition Metals for the Treatment of Cancer

Johnstone, T. C.; Suntharalingam, K.; Lippard, S. J.

Phil. Trans. R. Soc. A 2015, 373, 20140185.

 

19. Oxidative Halogenation of Cisplatin and Carboplatin: Synthesis, Spectroscopy, and Crystal and Molecular Structures of Pt(IV) Prodrugs

Johnstone, T. C.; Alexander, S. M.; Wilson, J. J.; Lippard S. J.

Dalton Trans. 2015, 44, 119-129.

 

18. Improvements in the Synthesis and Understanding of the Iodo-bridged Intermediate en Route to the Pt(IV) Prodrug Satraplatin

Johnstone, T. C.; Lippard, S. J.

Inorg. Chim. Acta 2015, 424, 254-259.

 

17. A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex

Suntharalingam, K.; Lin, W.; Johnstone, T. C.; Lippard S. J.

J. Am. Chem. Soc. 2014, 136, 14413-14416.

 

16. Pt(IV) Prodrugs Designed to Bind to Human Serum Albumin for Drug Delivery

Zheng, Y.-R.; Suntharalingam, K.; Johnstone, T. C.; Yoo, H.; Lin, W.; Brooks, J. G.; Lippard, S. J.

J. Am. Chem. Soc. 2014, 136, 8790-8798.

 

15. Structural and Mechanistic Studies of Polymerase η Bypass of Phenanthriplatin DNA Damage

Gregory, M. T.; Park, G. Y.; Johnstone, T. C., Lee, Y.-S.; Yang, W.; Lippard, S. J.

Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 9133-9138.

 

14. Reinterpretation of the Vibrational Spectroscopy of the Medicinal Bioinorganic Synthon c,c,t-[Pt(NH3)2Cl2(OH)2]

Johnstone, T. C.; Lippard, S. J.

J. Biol. Inorg. Chem. 2014, 19, 667-674.

 

13. A Fast and Selective Near-Infrared Fluorescent Sensor for Multicolor Imaging of Biological Nitroxyl

Wrobel, A. T.; Johnstone, T. C.; Deliz-Liang, A.; Lippard, S. J.; Rivera Fuentes, P. M.

J. Am. Chem. Soc. 2014, 136, 4697-4705.

 

12. The Chiral Potential of Phenanthriplatin and the Influence It Has on Guanine Binding

Johnstone, T. C.; Lippard, S. J.

J. Am. Chem. Soc. 2014, 136, 2126-2134.

 

11. Effects of Monofunctional Platinum Agents on Bacterial Growth: A Retrospective Study

Johnstone, T. C.; Alexander, S. M.; Lin, W.; Lippard, S. J.

J. Am. Chem. Soc. 2014, 136, 116-118.

 

10. Understanding and Improving Platinum Anticancer Drugs – Phenanthriplatin

Johnstone, T. C.; Park, G. Y.; Lippard, S. J.

Anticancer Res. 2014, 34, 471-476.

 

9. The Crystal Structure of Oxaliplatin: A Case of Overlooked Pseudo Symmetry

Johnstone, T. C.

Polyhedron 2014, 67, 429-435.

 

8. Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways

Suntharalingam, K.; Johnstone, T. C.; Bruno, P. M.; Lin, W.; Hemann, M. T.; Lippard, S. J.

J. Am. Chem. Soc. 2013, 135, 14060-14063.

*Highlighted by Chemical Research in Toxicology in DOI: 10.1021/tx4003897

 

7. Monofunctional and Higher-Valent Platinum Anticancer Agents

Johnstone, T. C.; Wilson, J. J.; Lippard, S. J.

Inorg. Chem. 2013, 52, 12234–12249.

*Inorganic Chemistry Forum Issue on Metals in Health and Medicine

 

6. The Effect of Ligand Lipophilicty on the Nanoparticle Encapsulation of Pt(IV) Prodrugs

Johnstone, T. C.; Lippard, S. J.

Inorg. Chem. 2013, 52, 9915–9920.

*Invited front cover

 

5. Nanoparticle Encapsulation of Mitaplatin and the Effect Thereof on In Vitro Properties

Johnstone, T. C.; Kulak, N.; Prigden, E. M.; Farokhzad, O. C.; Langer, R.; Lippard, S. J.

 ACS Nano 2013, 7, 5675-5683.

*Highlighted by ACS Nano in DOI: 10.1021/nn403220e

 

4. Conformational Isomerism of trans-[Pt(NH2C6H11)2I2] and the Classical Wernerian Chemistry of [Pt(NH2C6H11)4]X2 (X = Cl, Br, I)

Johnstone, T. C.; Lippard, S. J.

Polyhedron 2013, 52, 565-575.

 

3. Permethylated Salts and Radicals Derived from Azo peri-Naphthalenes

Bohle, D.; Chua, Z.; Johnstone, T.; Perepichka, I.; Rosadiuk, K.

ChemPlusChem 2012, 77, 387-395.

 

2. Reinforcement with Cellulose Nanocrystals of Poly(vinyl alcohol) Hydrogels Prepared by Cyclic Freezing and Thawing

Abitbol, T.; Johnstone, T.; Quinn, T. M.; Gray, D. G.

Soft Matter 2011, 7, 2373-2379.

 

1. Hydrogen-Bonding Asymmetric Metal Catalysis with alpha-Amino Acids: A Simple and Tunable Approach to High Enantioinduction

Lu, Y. D.; Johnstone, T. C.; Arndtsen, B. A.

J. Am. Chem. Soc. 2009, 131, 11284-11285.